With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and girls in gym shower having sex vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
This product may be unsafe when used before surgery or other medical procedures.
In a study including both in vivo and in vitro models, C.
The seeds contain a lignan glycoside known as tracheloside 11 ; serotonin derivatives and their glucosides have been found in the seed extract.
A study to determine the safety of safflower oil showed no adverse effects on liver enzymes and renal parameters eg, uric acid, blood urea nitrogen, creatinine at 10 g of oil per day.
Neonate survival rates in mice receiving these doses calculated at days 5, 15, 25, and 42 after birth were decreased compared with controls.
Local application of safflower increased expression of basic fibroblast growth factor bFGF and collagen type I protein, improved tensile strength of the tendon, and increased adhesion.
Specifically, it is believed to facilitate the formation of prostanoids, correct bone loss in women following ovariectomy, and increase the intestinal absorption of calcium.